The major advantage of the HSC engraftment model (humanized SRC-SCID) is that the human T and B cells develop from human stem cells engrafted in the mouse, undergo negative selection during differentiation into T and B cells, and are consequently tolerant of the mouse host. This kind of mouse model has been used to identify a pluripotent stem cell, termed “scid-repopulating cell” (SRC) that is more original than any of the hemopoietic stem cell populations identified using the currently available in vitro methodology. Intravenous injection of irradiated SCID mice with human bone marrow, cord blood, or G-CSF cytokine-mobilized peripheral blood mononuclear cells which are all rich in human hemopoietic stem cell activity, leads to the engraftment of a human hemopoietic system in the murine recipient. The discovery of the severe combined immunodeficiency (SCID) mouse mutation has provided a useful tool to establish small animal models as hosts for the in vivo analysis of normal and malignant human pluripotent hemopoietic stem cells. With years of experience in animal model, Creative Biolabs can provide the validated humanized SRC SCID mice for our worldwide clients to evaluate the safety and efficacy of potential novel agents to modulate the immune system. The humanized SRC-SCID model is established by injecting newborn or adult immunodeficient mice with HSCs from a variety of sources and has been regarded as a supreme in vivo model for long-term studies in the fields of immuno-oncology, infectious disease, and graft versus host disease. “Humanized” mouse model of immunity refers to normal, immunocompetent mouse expressing human genes by transgenesis (such as HLA or human immunoglobulin transgenic mice) or to immunodeficient mouse engrafted with human hematopoietic and lymphoid cells or tissues. Immunodeficient mice engrafted with human cells/tissues have provided a potential approach for the study of human immunobiology. Pharmacology and Pharmacodynamics Studies.Developability Assessment of Biopharmaceutical Candidates.Small-Angle X-ray and Neutron Scattering.Nuclear Magnetic Resonance (NMR) Spectroscopy.Natural Bioactive Compound Target Identification.In Silico Functional Analysis for Fungi.Computer-Aided Target Identification and Validation.Identification of Biomarkers by ORFeome Phage Display.Target Discovery for Cancer Immunotherapy.

Scid mouse